12th Annual Course
12th Course on the BBB in CNS Drug Development
on site
Principles, Transport Kinetics, Methods & Translation to humans
4 – 6th October 2023, Uppsala, Sweden
Following the previously successful ones, the 12th Annual Course on the BBB in CNS Drug Development is organized in 2023 as a 3-day course! It has a new schedule and significantly updated and expanded content, covering both small drug molecules and biologics.
Below you can find all relevant information on the program and registration
The Program
DAY I: Wednesday Oct 4th
Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles
09.00 – 09.30 | Welcome, introduction |
09.30 – 10.00 | BBB Morphology, Anatomy, Physiology and Function |
10.00 – 10.30 | Coffee and tea |
10.30 – 11.30 | Mechanism of BBB transport intrabrain distribution including integrated exercise |
11.30 – 12.30 | BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles, including integrated exercise |
12.30 – 13.30 | Lunch |
Experimental methods/approaches for investigating BBB transport and intra-brain distribution
13.30 – 13.50 | In vitro methods (cell cultures, monolayers) |
13.50 – 14.10 | In situ methods (brain sampling techniques) |
14.10 – 14.30 | In vivo monitoring methods: CSF & microdialysis |
14.30 – 14.45 | In vivo monitoring methods: PET (time, space, not unbound, terminology vs PK), CT, MRI, gadolinium etc. |
14.45 – 15.30 | Coffee and tea |
15.30 – 16.30 | Combinatory Mapping Approach to determine distribution of drugs between different brain sites, including integrated exercise |
16.30 – 17.00 | Exercise on BBB and intra-brain factors on obtained target site concentrations |
17.00 – 17.30 | Summing up and discussion of Day I |
18:00 | Dinner at the course hotel |
DAY II: Thursday Oct 5th
Approaches to improve CNS target site delivery
09.00 – 09.15 | Use of active transporters for efflux and influx |
09.15 – 09.30 | Invasive methods (mannitol infusion, injections,…) |
09.30 – 09.40 | Focused ultra-sound |
09.40 – 10.10 | Nanocarriers as a field with promise |
10.10 – 10.40 | Coffee and tea |
10.40 – 11.40 | Use of receptor-mediated transport for large molecules |
Computational methods to investigate and predict BBB transport and intrabrain distribution
11.40 – 12.40 | Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations |
12.40 – 13.40 | Lunch |
13.40 – 14.00 | In silico methods |
14.00 – 14.30 | CNS PBPK model approaches- (ULEICNSPK3.0) |
14.30 -15.00 | Applications on CNS PBPK |
15.00 – 15.30 | Coffee and tea |
15.30 – 16.00 | Sources of variability in CNS drug distribution |
16.00 – 17.00 | Hands-on exercise Shiny App Part 1 – for animals |
17.00 – 17.30 | Summing up and discussion of Day II |
18.00 | Dinner downtown |
DAY III: Friday Oct 6th
Integration and translation (to human) of CNS drug delivery principles
09.00 – 10.00 | Translational PK and PKPD relationships of CNS active drugs |
10.00 – 10.30 | Coffee and tea |
10.30 – 11.00 | Transporters and their translation between species |
11.00 – 12.00 | Hands-on exercise Shiny App Part 2 – for humans |
12.00 – 13.00 | Lunch |
13.00 – 14.00 | Overall perspectives |
14.00 – 15.00 | Discussions in break-out rooms on learning experience – what has been important learning experiences for you? |
15.00 | End of course |
Evaluations from the previous BBB course in Uppsala
- I found the course to be very valuable for my present work: Average 9.1 on a 1 – 10 scale, where 10 is “very much”.
- I would very much like to recommend this course to colleagues: Average 9.5 on a scale 1 – 10, where 10 is “very much”.
Location
The course will be held at hotel Scandic Uplandia in the City Center of Uppsala, address Dragarbrunnsgatan 32, 75320 Uppsala, https://www.scandichotels.com/uplandia. Rooms can also be reserved at this hotel or at other Uppsala hotels.
Uppsala City Center can be reached from Stockholm International Airport Arlanda by taxi (can be reserved for pick-up at arrival by Uppsalataxi at +4618 100 000), bus or train. The travel to Uppsala takes around 30 min by taxi.
Fee
The course fee includes course attendance, course material, lunches, dinners and coffee/tea during breaks. It does not include accommodation.
Early payment:
PhD students* | € 1595,- (excl. VAT) |
Academic | € 1795,- (excl. VAT) |
Business | € 1995,- (excl. VAT) |
Regular pricing:
PhD students* | € 1895,- (excl. VAT) |
Academic | € 2095,- (excl. VAT) |
Business | € 2295,- (excl. VAT) |
For participants based in Sweden, please add VAT 25 %. Participants outside of Sweden do not need to pay VAT.
Registration Form
Please register by filling out the form below. A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email
Payment Information and alternatives
Udenaes Consulting
SEB (106 40 Stockholm, Sweden)
1) Pay directly to bank account
IBAN Account SE3850000000053681044384
BIC: ESSESESS
2) Pay via PayPal
3) Please ask by email for an invoice, specify participant and funding unit
Company Information
Udenaes Consulting
Bruksvagen 29
752 41 Uppsala, Sweden
+46 70 5301 147
udenaesconsulting@gmail.com
VAT: SE530124754901
Cancellation policy
In case of cancellation before September 1st 2023 payment will be restituted (-10% administration costs). In case of cancellation after September 1st 2023 there will be no restitution, but the participant may be exchanged for another participant.