12th Annual Course

12^th Course on the BBB in CNS Drug Development
on site

Principles, Transport Kinetics, Methods & Translation to humans

4 – 6th October 2023, Uppsala, Sweden

Following the previously successful ones, the 12th Annual Course on the BBB in CNS Drug Development is organized in 2023 as a 3-day course! It has a new schedule and significantly updated and expanded content, covering both small drug molecules and biologics.

Below you can find all relevant information on the program and registration

The Program

DAY I: Wednesday Oct 4th

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

09.00 – 09.30	Welcome, introduction
09.30 – 10.00	BBB Morphology, Anatomy, Physiology and Function
10.00 – 10.30	Coffee and tea
10.30 – 11.30	Mechanism of BBB transport intrabrain distribution including integrated exercise
11.30 – 12.30	BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles, including integrated exercise
12.30 – 13.30	Lunch

Experimental methods/approaches for investigating BBB transport and intra-brain distribution

13.30 – 13.50	In vitro methods (cell cultures, monolayers)
13.50 – 14.10	In situ methods (brain sampling techniques)
14.10 – 14.30	In vivo monitoring methods: CSF & microdialysis
14.30 – 14.45	In vivo monitoring methods: PET (time, space, not unbound, terminology vs PK), CT, MRI, gadolinium etc.
14.45 – 15.30	Coffee and tea
15.30 – 16.30	Combinatory Mapping Approach to determine distribution of drugs between different brain sites, including integrated exercise
16.30 – 17.00	Exercise on BBB and intra-brain factors on obtained target site concentrations
17.00 – 17.30	Summing up and discussion of Day I
18:00	Dinner at the course hotel

DAY II: Thursday Oct 5th

Approaches to improve CNS target site delivery

09.00 – 09.15	Use of active transporters for efflux and influx
09.15 – 09.30	Invasive methods (mannitol infusion, injections,…)
09.30 – 09.40	Focused ultra-sound
09.40 – 10.10	Nanocarriers as a field with promise
10.10 – 10.40	Coffee and tea
10.40 – 11.40	Use of receptor-mediated transport for large molecules

Computational methods to investigate and predict BBB transport and intrabrain distribution

11.40 – 12.40	Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations
12.40 – 13.40	Lunch
13.40 – 14.00	In silico methods
14.00 – 14.30	CNS PBPK model approaches- (ULEICNSPK3.0)
14.30 -15.00	Applications on CNS PBPK
15.00 – 15.30	Coffee and tea
15.30 – 16.00	Sources of variability in CNS drug distribution
16.00 – 17.00	Hands-on exercise Shiny App Part 1 – for animals
17.00 – 17.30	Summing up and discussion of Day II
18.00	Dinner downtown

DAY III: Friday Oct 6th

Integration and translation (to human) of CNS drug delivery principles

09.00 – 10.00	Translational PK and PKPD relationships of CNS active drugs
10.00 – 10.30	Coffee and tea
10.30 – 11.00	Transporters and their translation between species
11.00 – 12.00	Hands-on exercise Shiny App Part 2 – for humans
12.00 – 13.00	Lunch
13.00 – 14.00	Overall perspectives
14.00 – 15.00	Discussions in break-out rooms on learning experience – what has been important learning experiences for you?
15.00	End of course

Evaluations from the previous BBB course in Uppsala

I found the course to be very valuable for my present work: Average 9.1 on a 1 – 10 scale, where 10 is “very much”.
I would very much like to recommend this course to colleagues: Average 9.5 on a scale 1 – 10, where 10 is “very much”.

Location

The course will be held at hotel Scandic Uplandia in the City Center of Uppsala, address Dragarbrunnsgatan 32, 75320 Uppsala, https://www.scandichotels.com/uplandia. Rooms can also be reserved at this hotel or at other Uppsala hotels.

Uppsala City Center can be reached from Stockholm International Airport Arlanda by taxi (can be reserved for pick-up at arrival by Uppsalataxi at +4618 100 000), bus or train. The travel to Uppsala takes around 30 min by taxi.

Fee

The course fee includes course attendance, course material, lunches, dinners and coffee/tea during breaks. It does not include accommodation.

Early payment:

PhD students*	€ 1595,- (excl. VAT)
Academic	€ 1795,- (excl. VAT)
Business	€ 1995,- (excl. VAT)

Regular pricing:

PhD students*	€ 1895,- (excl. VAT)
Academic	€ 2095,- (excl. VAT)
Business	€ 2295,- (excl. VAT)

For participants based in Sweden, please add VAT 25 %. Participants outside of Sweden do not need to pay VAT.

Registration Form

Please register by filling out the form below. A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email

Payment Information and alternatives

Udenaes Consulting
SEB (106 40 Stockholm, Sweden)
1) Pay directly to bank account
IBAN Account SE3850000000053681044384
BIC: ESSESESS
2) Pay via PayPal

3) Please ask by email for an invoice, specify participant and funding unit

Cancellation policy

In case of cancellation before September 1st 2023 payment will be restituted (-10% administration costs). In case of cancellation after September 1st 2023 there will be no restitution, but the participant may be exchanged for another participant.

Courses on the BBB in CNS Drug Development