Program

12th Course on the BBB in CNS Drug Development Online

Principles, Transport Kinetics, Methods & Translation to humans

5 – 7 October 2022, Uppsala, Sweden


The Program – 5, 6 and 7 Oct 2022

DAY I: Wednesday Oct 5th

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

09.00 – 09.30 Welcome and Introduction
09.30 – 10.00 BBB Morphology, Anatomy, Physiology and Function
10.00 – 10.30 Coffee and tea
10.30 – 11.30 Mechanism of BBB transport intrabrain distribution including integrated exercise
11.30 – 12.30 BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles, including integrated exercise
12.30 – 13.30 Lunch

Experimental methods/approaches for investigating BBB transport and intra-brain distribution

13.30 – 13.50 In vitro methods (cell cultures, monolayers)
13.50 – 14.10 In situ methods (brain sampling techniques)
14.10 – 14.30 In vivo monitoring methods: CSF & microdialysis
14.30 – 14.45 In vivo monitoring methods: PET (time, space, not unbound, terminology vs PK), CT, MRI, gadolinium etc.
14.45 – 15.30 Coffee and tea
15.30 – 16.30 Combinatory Mapping Approach to determine distribution of drugs between different brain sites, including integrated exercise
16.30 – 17.00 Exercise on BBB and intra-brain factors on obtained target site concentrations
17.00 – 17.30 Summing up and discussion of Day I
18:00 Dinner at the course hotel

DAY II: Thursday Oct 6th

Approaches to improve CNS target site delivery

09.00 – 09.15 Use of active transporters for efflux and influx
09.15 – 09.30 Invasive methods (mannitol infusion, injections,…)
09.30 – 09.40 Focused ultra-sound
09.40 – 10.10 Nanocarriers as a field with promise
10.10 – 10.40 Coffee and tea
10.40 – 11.40 Use of receptor-mediated transport for large molecules

Computational methods to investigate and predict BBB transport and intrabrain distribution
11.40 – 12.40 Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations
12.40 – 13.40 Lunch
13.40 – 14.00 In silico methods
14.00 – 14.30 CNS PBPK model approaches- (ULEICNSPK3.0)
14.30 -15.00 Applications on CNS PBPK
15.00 – 15.30 Coffee and tea
15.30 – 16.00 Sources of variability in CNS drug distribution
16.00 – 17.00 Hands-on exercise Shiny App Part 1 – for animals
17.00 – 17.30 Summing up and discussion of Day II
18.00 Dinner downtown

DAY III: Friday Oct 7th

Integration and translation (to human) of CNS drug delivery principles

09.00 – 10.00 Translational PK and PKPD relationships of CNS active drugs
10.00 – 10.30 Coffee and tea
10.30 – 11.00 Transporters and their translation between species
11.00 – 12.00 Hands-on exercise Shiny App Part 2 – for humans
12.00 – 13.00 Lunch
13.00 – 14.00 Overall perspectives
14.00 – 15.00 Discussions in break-out rooms on learning experience – what has been important learning experiences for you?
15.00 End of course

For participants based in Sweden, please add VAT 25 %. Participants outside of Sweden do not need to pay VAT.

*PhD students should accompany this form by a letter of their supervisor to ensure the status of PhD student.

Evaluations from the previous BBB course in Uppsala

  • I found the course to be very valuable for my present work: Average 9.1 on a 1 – 10 scale, where 10 is “very much”.
  • I would very much like to recommend this course to colleagues: Average 9.5 on a scale 1 – 10, where 10 is “very much”.