13th Annual Course

13th Course on the BBB in CNS Drug Development
online

Principles, Transport Kinetics, Methods & Translation to humans

23, 24, 29, 30, 31 January 2024, on-line, hosted in Leiden, the Netherlands

Following the previously successful ones, the 13th Annual Course on the BBB in CNS Drug Development is organized in 2024 as a 5 half-days on-line course! It has a new schedule and significantly updated and expanded content, covering both small drug molecules and biologics.

Below you can find all relevant information on the program and registration

The Program

DAY I: Tuesday Jan 23rd

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

15.00 – 15.30 Welcome, introduction
15.30 – 16.00 BBB Morphology, Anatomy, Physiology and Function
16.00 – 16.10 10 min break
16.10 -17.10 Mechanism of BBB transport intrabrain distribution
17.10 – 17.40 30 min break
17.40 – 18.40 BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles
18.40 – 19.00 Summing up and discussion of Day I

DAY II: Wednesday Jan 24th

Experimental methods/approaches for investigating BBB transport and intra-brain distribution

15.00 – 15.15 Introduction to today's theme
15.15 – 15.35 In vitro methods (cell cultures)
15.35 – 15.55 In situ methods (brain sampling techniques)
15.55 – 16.05 10 min break
16.05 – 16.25 In vivo monitoring methods: CSF & microdialysis
16.25 – 16.40 In vivo monitoring methods: PET, CT, MRI
16.40 – 17.10 30 min break
17.10 – 18.10 Combinatory Mapping Approach to determine distribution of drugs between different brain sites
18.10 – 18.40 Hands-on exercise: BBB and intra-brain factors for obtaining target site concentrations
18.40 – 19.00 Summing up and discussion of Day II

DAY III: Monday Jan 29th

Computational Methods to Investigate and Predict BBB Transport and Intra-brain Distribution 

15.00 – 15.15 Introduction to today's theme
15.15 – 16.10 Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations
16.10 – 16.20 Lunch
16.20 – 16.40 In silico methods
16.40 – 17.10 CNS PBPK modeling approaches
17.10 -17.40 Applications of CNS PBPK modeling predictions (LEICNSPK3.0)
17.40 – 18.10 30 min break
18.10 – 18.40 Sources of variability in CNS drug distribution
18.40 – 19.00 Summing up and discussion of Day III

DAY IV: Tuesday Jan 30th

Approaches to Improve CNS Target Site Delivery 

15.00 – 15.15 Introduction to today's theme
15.15 – 15.30 Use of active transporters for efflux and influx
15.30 – 15.40 Invasive methods for CNS target site delivery
15.40 – 15.50 Focused ultra-sound
15.50 – 16.00 10 min break
16.00 – 17.00 Use of receptor-mediated transport for large molecules
17.00 – 17.30 30 min break
17.30 – 18.00 Nanocarriers as a field with promise
18.00 – 18.40 Hands-on exercise: Shiny App – CNS PBPK model – Part 1 – animals
18.40 – 19.00 Summing up and discussion of Day IV

DAY IV: Wednesday Jan 31st

Integration and Translation (to human) of CNS Drug Delivery Principles 

15.00 – 15.15 Introduction on integration and translation of CNS drug delivery principles
15.15 – 16.00 Translational PK and PKPD relationships of CNS active drugs
16.00 – 16.10 10 min break
16.10 – 17.10 Hands-on exercise: Shiny App – CNS PBPK model – Part 2 – animal to human translation
17.10 – 17.40 30 min break
17.40 – 18.10 Overall perspectives
18.10 – 18.40 Discussions on learning experience and final questions
18.40 End of course

Evaluations from the previous BBB course

  • I found the course to be very valuable for my present work: Average 9.1 on a 1 – 10 scale, where 10 is “very much”.
  • I would very much like to recommend this course to colleagues: Average 9.5 on a scale 1 – 10, where 10 is “very much”.

Fee

The course fee includes course attendance and course material.

Early payment:

PhD students* € 1595,- (excl. VAT)
Academic € 1795,- (excl. VAT)
Business € 1995,- (excl. VAT)

Regular pricing:

PhD students* € 1895,- (excl. VAT)
Academic € 2095,- (excl. VAT)
Business € 2295,- (excl. VAT)

Registration Form

Please register by filling out the form below. A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email

    Name participant:

    Job title:

    Email address:

    Affiliation:

    Date:

    Please tick the appropriate:

    Payment completed before or on December 1st 2023:
    PhD students: € 1595,-Academic: € 1795,-Business: € 1995,-

    Payment completed after December 1st 2023:
    PhD students: € 1895,-Academic: € 2095,-Business: € 2295,-

    PhD students should accompany a letter from their supervisor to ensure the status of PhD student:

    Payment information

    In Focus
    ING Bank (PO Box 2338, 3000 CH Rotterdam, The Netherlands)
    IBAN Account NL47 INGB 0651 4673 73
    BIC: INGBNL2A

    Company Information

    In Focus
    SbN Doormanlaan 8
    2243 AL Wassenaar
    The Netherlands
    VAT: NL 8159.63.567.B.01
    C. of C. no: 272 830 74

    Cancellation policy

    In case of cancellation before December 1st 2023 payment will be restituted (-10% administration costs). In case of cancellation after December 1st 2023 there will be no restitution, but the participant may be exchanged for another participant.