12th Annual Course

12th Course on the BBB in CNS Drug Development
on site

Principles, Transport Kinetics, Methods & Translation to humans

4- 6th October 2023, Uppsala, Sweden

Following the previously successful ones, the 12th Annual Course on the BBB in CNS Drug Development is organized in 2023 as a 3-day course! It has a new schedule and significantly updated and expanded content, covering both small drug molecules and biologics.

Below you can find all relevant information on the program and registration

The Program

DAY I: Wednesday Oct 4th

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

09.00 – 09.30 Welcome a: Wednesday Oct 5thnd Introduction
09.30 – 10.00 BBB Morphology, Anatomy, Physiology and Function
10.00 – 10.30 Coffee and tea
10.30 – 11.30 Mechanism of BBB transport intrabrain distribution including integrated exercise
11.30 – 12.30 BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles, including integrated exercise
12.30 – 13.30 Lunch

Experimental methods/approaches for investigating BBB transport and intra-brain distribution

13.30 – 13.50 In vitro methods (cell cultures, monolayers)
13.50 – 14.10 In situ methods (brain sampling techniques)
14.10 – 14.30 In vivo monitoring methods: CSF & microdialysis
14.30 – 14.45 In vivo monitoring methods: PET (time, space, not unbound, terminology vs PK), CT, MRI, gadolinium etc.
14.45 – 15.30 Coffee and tea
15.30 – 16.30 Combinatory Mapping Approach to determine distribution of drugs between different brain sites, including integrated exercise
16.30 – 17.00 Exercise on BBB and intra-brain factors on obtained target site concentrations
17.00 – 17.30 Summing up and discussion of Day I
18:00 Dinner at the course hotel

DAY II: Thursday Oct 5th

Approaches to improve CNS target site delivery

09.00 – 09.15 Use of active transporters for efflux and influx
09.15 – 09.30 Invasive methods (mannitol infusion, injections,…)
09.30 – 09.40 Focused ultra-sound
09.40 – 10.10 Nanocarriers as a field with promise
10.10 – 10.40 Coffee and tea
10.40 – 11.40 Use of receptor-mediated transport for large molecules

Computational methods to investigate and predict BBB transport and intrabrain distribution
11.40 – 12.40 Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations
12.40 – 13.40 Lunch
13.40 – 14.00 In silico methods
14.00 – 14.30 CNS PBPK model approaches- (ULEICNSPK3.0)
14.30 -15.00 Applications on CNS PBPK
15.00 – 15.30 Coffee and tea
15.30 – 16.00 Sources of variability in CNS drug distribution
16.00 – 17.00 Hands-on exercise Shiny App Part 1 – for animals
17.00 – 17.30 Summing up and discussion of Day II
18.00 Dinner downtown

DAY III: Friday Oct 6th

Integration and translation (to human) of CNS drug delivery principles

09.00 – 10.00 Translational PK and PKPD relationships of CNS active drugs
10.00 – 10.30 Coffee and tea
10.30 – 11.00 Transporters and their translation between species
11.00 – 12.00 Hands-on exercise Shiny App Part 2 – for humans
12.00 – 13.00 Lunch
13.00 – 14.00 Overall perspectives
14.00 – 15.00 Discussions in break-out rooms on learning experience – what has been important learning experiences for you?
15.00 End of course

For participants based in Sweden, please add VAT 25 %. Participants outside of Sweden do not need to pay VAT.

*PhD students should accompany this form by a letter of their supervisor to ensure the status of PhD student.

Evaluations from the previous BBB course in Uppsala

  • I found the course to be very valuable for my present work: Average 9.1 on a 1 – 10 scale, where 10 is “very much”.
  • I would very much like to recommend this course to colleagues: Average 9.5 on a scale 1 – 10, where 10 is “very much”.

Location

Information will follow

Fee

The course fee includes course attendance and course material.

Early payment:

PhD students* € 1495,- (excl. VAT)
Academic € 1695,- (excl. VAT)
Business € 1895,- (excl. VAT)

Regular pricing:

PhD students* € 1795,- (excl. VAT)
Academic € 1995,- (excl. VAT)
Business € 2195,- (excl. VAT)

For participants based in Sweden, please add VAT 25 %. Participants outside of Sweden do not need to pay VAT.

*PhD students should accompany this form by a letter of their supervisor to ensure the status of PhD student

Registration Form

Please register by filling out the form below. A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email

    Name participant:

    Job title:

    Email address:

    Affiliation:

    Date:

    Fee includes course attendance, course material, lunches, dinners, coffee/tea at start and during breaks. It does not include accommodation. Please tick the appropriate:

    Payment completed before or on September 1st 2023:
    PhD students: € 1495,-Academic: € 1695,-Business: € 1895,-

    Payment completed after September 1st 2023:
    PhD students: € 1795,-Academic: € 1995,-Business: € 2195,-

    PhD students should accompany a letter from their supervisor to ensure the status of PhD student:

    Payment information

    Udenaes Consulting
    SEB (106 40 Stockholm, Sweden)
    IBAN Account SE3850000000053681044384
    BIC: ESSESESS

    Company Information

    Udenaes Consulting
    Bruksvagen 29
    752 41 Uppsala, Sweden
    +46 70 5301 147
    udenaesconsulting@gmail.com
    VAT: SE530124754901

    Cancellation policy

    In case of cancellation before July 30 2023 payment will be restituted (-10% administration costs). In case of cancellation after July 30 2023 there will be no restitution, but the participant may be exchanged for another participant.