14th Annual Course

14th Course on the BBB in CNS Drug Development
hosted in Leiden, the Netherlands

Principles, Transport Kinetics, Methods & Translation to humans

2 – 4th October 2024, Leiden, the Netherlands

Following the previously successful ones, the 14th Annual Course on the BBB in CNS Drug Development is organized in 2024 as a 3-day on site course! It has a new schedule and significantly updated and expanded content, covering both small drug molecules and biologics.

Below you can find all relevant information on the program, registration and payment possibilities

The Program

DAY I: Wednesday October 2nd

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

09.00 – 09.30 Welcome, introduction
09.30 – 10.00 BBB Morphology, Anatomy, Physiology and Function
10.00 – 10.30 Coffee and tea
10.30 -11.30 Mechanism of BBB transport intrabrain distribution including integrated exercise
11.30 – 12.30 BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles, including integrated exercise
12.30 – 13.30 Lunch
13.30 – 13.50 In vitro methods (cell cultures, monolayers)
13.50 – 14.10 In situ methods (brain sampling techniques)
14.10 – 14.30 In vivo monitoring methods: CSF & microdialysis
14.30 – 14.45 In situ methods (brain sampling techniques)In vivo monitoring methods: PET (time, space, not unbound, terminology vs PK), CT, MRI, gadolinium etc.
14.45 – 15.30 Coffee and tea
15.30 – 16.30 Combinatory Mapping Approach to determine distribution of drugs between different brain sites, including integrated exercise
16.30 – 17.00 Exercise on BBB and intra-brain factors on obtained target site concentrations
17.00 – 17.30 Summing up and discussion of Day I
18.00 Dinner at the course hotel

DAY II: Thursday October 3rd

Approaches to improve CNS target site delivery 

09.00 – 09.15 Use of active transporters for efflux and influx
09.15 – 09.30 Invasive methods
09.30 – 09.40 Focused ultra-sound
09.40 – 10.10 Nanocarriers as a field with promise
10.10 – 10.40 Coffee and tea
10.40 – 11.40 Use of receptor-mediated transport for large molecules

Computational methods to investigate and predict BBB transport and intrabrain distribution
11.40 – 12.40 Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations
12.40 – 13.40 Lunch
13.40 – 14.00 In silico methods
14.00 – 14.30 CNS PBPK model approaches- (ULEICNSPK3.0)
14.30 – 15.00 Applications on CNS PBPK
15.00 – 15.30 Coffee and tea
15.30 – 16.00 Sources of variability in CNS drug distribution
16.00 – 17.00 Hands-on exercise Shiny App Part 1 – for animals
17.00 – 17.30 Summing up and discussion of Day II
18.00 Dinner downtown

DAY III: Friday October 5th

Integration and translation (to human) of CNS drug delivery principles 

09.00 – 10.00 Translational PK and PKPD relationships of CNS active drugs
10.00 – 10.30 Coffee and tea
10.30 – 11.00 Transporters and their translation between species
11.00 – 12.00 Hands-on exercise Shiny App Part 2 – for humans
12.00 – 13.00 Lunch
13.00 – 14.00 Overall perspectives
14.00 – 15.00 Discussions in break-out rooms on learning experience – what has been important learning experiences for you?
15.00 End of course

Evaluations from the previous BBB course

  • I found the course to be very valuable for my present work: Average 9.1/10
  • I would very much like to recommend this course to colleagues: Average 10/10

Location

The course will be held at hotel Leiden, close to the city center of Leiden, address Haagse Schouwweg 14, 2332 KG Leiden ( https://www.hotelleiden.nl ). Rooms can also be reserved at this hotel or at other Leiden hotels.

Leiden City Center can be reached from Schiphol International Airport Schiphol by train, which takes around 20 min.

Fee

The course fee includes course attendance and course material.

Early payment (before September 1st):

PhD students* € 1795,- (excl. VAT)
Academic € 1995,- (excl. VAT)
Business € 2195,- (excl. VAT)

Regular pricing:

PhD students* € 1995,- (excl. VAT)
Academic € 2195,- (excl. VAT)
Business € 2395,- (excl. VAT)

For participants based in the Netherlands, please add VAT 21 %. Participants outside of the Netherlands do not need to pay VAT.

Registration Form

Please register by filling out the form below. A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email

    Name participant:

    Job title:

    Email:

    Affiliation:

    Date:

    Please tick the appropriate:

    Payment completed before or on September 1st:

    PhD students: € 1795,-Academic: € 1995,-Business: € 2195,-

    Payment completed after September 1st:

    PhD students: € 1995,-Academic: € 2195,-Business: € 2395,-

    PhD students should accompany a letter from their supervisor to ensure the status of PhD student:

    Payment information

    1) Pay directly to bank account
    In Focus
    ING Bank (PO Box 2338, 3000 CH Rotterdam, The Netherlands)
    IBAN Account NL47 INGB 0651 4673 73
    BIC: INGBNL2A
    2) Pay via PayPal

    3) Please ask by email for an invoice, specify participant and funding unit

    Company Information

    In Focus, SbN Doormanlaan 8, 2243 AL Wassenaar, The Netherlands
    VAT: NL 8159.63.567.B.01, C. of C. no: 272 830 74
    ING Bank (PO Box 2338, 3000 CH Rotterdam, The Netherlands)
    IBAN Account NL47 INGB 0651 4673 73
    BIC: INGBNL2A

    Cancellation policy

    In case of cancellation before September 1st 2024 payment will be restituted (-10% administration costs). In case of cancellation after September 1st 2024 there will be no restitution, but the participant may be exchanged for another participant.