Program

9th Annual Course on the BBB in Drug Development 2018 (Leiden, The Netherlands)

October 15, 2018 – October 17, 2018

Monday Oct 15th 2018

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

09.00 – 09.30 Welcome and Introduction
09.30 – 10.00 BBB Morphology, Anatomy, Physiology and Function
10.00 – 10.30 Coffee and Tea
10.30 – 11.30 BBB Transport Modes
11.30 – 12.30 Larger Molecules and Approaches to Overcome Problems in CNS Drug Delivery
12.30 – 13.30 Lunch
13.30 – 14.30 General Pharmacokinetic (PK) Principles
14.30 – 15.30 BBB transport: Rate and Extent. Impact on Brain vs Plasma PK
15.30 – 16.00 Coffee and Tea
16.00 – 16.45 Factors in CNS Drug Effects
16.45 – 17.30 Discussions BBB Research Issues from Participants
18.00 – 20.00 Drinks and Dinner at Course Hotel

Tuesday Oct 16th 2018

Principles and Methods for Investigating BBB Transport 

09.00 – 09.30 In Vitro Methods (Cell Cultures, Monolayers)
09.30 – 10.00 In Situ Methods (Brain Sampling Techniques)
10.00 – 10.30 Coffee and Tea
10.30 – 11.30 In Vivo Monitoring Methods: CSF & Microdialysis
11.30 – 12.00 In Vivo Monitoring Methods: PET
12.00 – 13.00 Lunch
13.00 – 13.45 Sources of Variability in CNS Drug Distribution
13.45 – 14.45 In Vitro Methods (Brain Slice and – Homogenate Uptake)
14.45 – 15.15 Coffee and tea
15.15 – 15.45 Factors that Influence Unbound Brain Pharmacokinetics
15.45 – 17.15 Hands-on Computer Exercise and Discussion: Plasma and Brain PK Relationships
18.00 – 21.30 Drinks and Dinner downtown Leiden

Wednesday Oct 17th 2018

Integration and Translation of CNS Drug Delivery Principles

09.00 – 10.00 Translational PK/PD Relationships of CNS Active Drugs
10.00 – 10.30 Coffee and Tea
10.30 – 11.30 What Parameters to Use in CNS Drug Development?
11.30 – 13.00 Hands-on Assignment on BBB Transport and Intracellular Distribution
13.00 – 14.00 Lunch
14.00 – 14.30 Discussion on Hands-on Assignment
14.15 – 14.45 Concluding Discussions and Perspectives
14.45 – 15.15 Certificates and Final Comments

Evaluations from the previous BBB course in Uppsala

  • I found the course to be very valuable for my present work: Average 9.1 on a 1 – 10 scale, where 10 is “very much”.
  • I would very much like to recommend this course to colleagues: Average 9.5 on a scale 1 – 10, where 10 is “very much”.

Citations from the BBB course participants:

  • “Thank you for the intensive course on brain pharmacokinetics. The structure and materials are well – organized. It is great that there was possibility to discuss aspects related to work and do practical assignments”
  • “Nice course with the opportunity to discuss immediately”
  • “Very good with some hands – on especially with Berkeley Madonna .”
  • “Very nice and very interesting. Equations and calculations I found a little difficult, but the use of hands – on exercises helped very much”
  • “Thank you for the high quality teaching, discussions and dinners. I would highly recommend the course to my colleagues and looking forward seeing you again”
  • “Personally I think you are very good teachers and very kind to us”